We have worked with dozens of clients at this point. It would not make much sense to document all of them here. These are a few recent cases, shown purely for demonstration purposes. All clients consented to anonymous publication of their data. No names, no identifying details. The panels are real. The timestamps are real. The protocols that produced the changes are summarized but not published in full.

Case 02

Elevated liver markers, broken lipids, 17 kg in 20 weeks.

Age 50 Role Founder Program length 20 weeks Status Completed

A fifty-year-old founder running a real business. From the outside everything looked dialled in, and he believed it was. The first panel said otherwise. His cholesterol was out of range across every marker, his liver enzymes were elevated in a pattern consistent with fatty liver, he was carrying significant excess weight, his energy was gone, and his focus came and went without any pattern he could name.

Twenty weeks later he was seventeen kilograms lighter, with every flagged marker back in range, his liver indicators resolved, his energy back, and his focus restored. None of it was exotic. It was the right system built across all six blocks and then run, without skipping, for twenty weeks straight.

Week 0 Out of range
Body weight99 kg
Total cholesterol222 mg/dL
LDL cholesterol179 mg/dL
HDL cholesterol22 mg/dL
AST (liver)95 U/L
ALT (liver)217 U/L
Week 20 In range
Body weight82 kg
Total cholesterol172 mg/dL
LDL cholesterol107 mg/dL
HDL cholesterol49 mg/dL
AST (liver)27 U/L
ALT (liver)25 U/L

What we did

  • Nutrition

    Restructured macros around liver recovery. Removed inflammatory drivers. Built a sustainable eating pattern around his travel schedule.

  • Training

    Returning from a 3-month break. Started with full-body resistance protocol 5x/week, added zone-2 cardio for metabolic recovery.

  • Sleep

    Sleep window restructured. Weekend consistency built up over weeks 1 through 6.

  • Diagnostics

    Re-panel at week 10 and week 20 to confirm direction and re-calibrate.

  • Behavioural

    Weekly 1:1 calls, daily communication, real-time protocol adjustments.

Case 03

58. Doing all the right things. None of them helping.

Age 58 Role Business owner Program length Ongoing Status Ongoing

Fifty-eight years old, fasting intermittently, playing competitive padel three times a week, eating clean, and completely convinced he was operating at his peak. He only came to the program because a friend insisted, not because he thought anything was wrong.

His first panel showed inflammation at thirty times the upper reference, microcytic red cells, and a recent bout of malaria that had never fully resolved. The protocols he was running, intermittent fasting stacked on top of high-intensity padel, are perfectly sensible for a healthy person. He was not a healthy person at that point. So we took the high-intensity load off, rebuilt his nutrition around recovery rather than restriction, and put a strength program around the depleted state he was actually in.

Week 0 · Sep 2025 Inflammation 30x normal
C-Reactive Protein149 mg/L ref < 5
RBC5.93 x10¹²/L ref 4.5–5.5
MCV71.5 fL ref 83–101
MCH22.1 pg ref 27–32

Re-panel scheduled for week 12. Results published when available.

What we did

  • Training

    Removed high-intensity padel. Built a recovery-first strength protocol.

  • Nutrition

    Stopped intermittent fasting. Rebuilt nutrient timing around recovery.

  • Diagnostics

    Full re-panel scheduled at week 12.

  • Behavioural

    Weekly 1:1, recovery-focused weekly check-ins.

Case 01 · The founder's own case

Rodrigo. Top 1% baseline. Still finding things to optimize. That is the point of running 150 markers.

Role Founder, Calibrate Health Program length Ongoing Status Optimized, fine-tuning

Yes, this is me. I include my own panel because running a health optimization company without being a client of your own program would be a bit awkward. For context: I have been training and optimizing seriously for about seven years, and for the last four to five of those I have been genuinely operating at a top 1% baseline. Good sleep, good nutrition, consistent training, full diagnostics run regularly. This is not a case of someone coming in broken. It is a case of what a 150-marker panel finds even when everything feels right.

The two markers worth explaining are SHBG and free testosterone. Total testosterone is strong. SHBG is elevated, which suppresses free testosterone (the form the body actually uses) to the lower end of the range. This is largely a consequence of a known exposure: eight months of isotretinoin in my teens for severe acne. Isotretinoin puts significant load on the liver, and elevated SHBG is a well-documented downstream effect in some cases. It is not a performance crisis. It is a specific target. The protocol is built around lowering SHBG through zone-2 training, gut support, and sleep consistency, and tracking whether free T follows up over the next panel.

The broader point is this: if a panel run on someone already optimizing seriously still finds actionable targets, imagine what it finds on someone who has never tested at all.

Current panel Optimization targets identified
Total testosterone658 ng/dL looks fine, hides the problem
Free testosterone19.8 pg/mL ref 19.0–51.0
SHBG53.9 nmol/L high, suppressing free T
Vitamin D24 ng/mL ref 30–100
F. prausnitzii (gut)0.98% ref 3.44–11.31

Re-panel scheduled for week 12. Results published when available.

What we did

  • Training

    Added zone-2 cardio block to existing strength protocol to lower SHBG and improve HRV.

  • Nutrition

    Gut-targeted protocol to rebuild F. prausnitzii (butyrate-producing keystone species).

  • Supplements

    Vitamin D protocol, gut-supportive stack.

  • Sleep

    Consistency rebuild (Whoop showed 71% consistency, poor).

  • Diagnostics

    Full re-panel at week 12.

Case 04

96 kg at baseline. 23 kg down in 6 months. Full system rebuild.

Role Founder Program length 6 months Status Ongoing

He started at 96 kilograms with elevated insulin and metabolic markers consistent with early insulin resistance. He had never had a baseline panel done, so he genuinely did not know what a healthy operating baseline looked like, because no one had ever measured his properly. The work was not a diet. It was rebuilding an entire operating system from the ground up, with sleep, nutrition, training, habits, and diagnostics all running in parallel from day one.

At six months he was 73 kilograms, down twenty-three, with his insulin markers reversed and his energy finally stable. He is still progressing.

Week 0 Metabolic markers flagged
Body weight96 kg
Fasting insulinElevated insulin resistance pattern
Body compositionExcess fat mass DEXA confirmed
Month 6 Markers reversed
Body weight73 kg -23 kg
Fasting insulinIn range
Body compositionSignificantly improved

What we did

  • Nutrition

    Complete diet overhaul. Built a whole-food protocol addressing the insulin pattern and supporting body recomposition.

  • Training

    Progressive resistance program plus structured cardio. Built from zero, scaled over 6 months.

  • Sleep

    Full sleep optimization protocol. Schedule, environment, consistency tracking.

  • Behavioural

    Weekly 1:1 calls, daily check-ins, habit system built around the client's schedule.

  • Diagnostics

    Baseline panel, re-panel at month 3, ongoing monitoring.

Case 05

Vitamin D deficient, genetic cardiovascular risk marker, body recomposition target.

Role Founder Program length Ongoing Status Ongoing

He was building a business, training five days a week, and looked completely fine from the outside. The standard ten-marker checkup agreed with that and called him normal. The 150-marker panel did not. It found three reversible deficiencies and one genetic cardiovascular risk marker, Lipoprotein(a), that most general practitioners never think to test for. That marker does not respond to lifestyle the way the others do, but the risk it carries can be substantially offset by optimizing everything around it, and that is exactly what his protocol was built to do.

The sleep problem he mentioned turned out to be work stress and an inability to switch off, on top of two or three coffees and energy drinks a day. His re-panel is scheduled for week twelve.

Week 0 · Dec 2025 3 deficiencies + genetic risk marker
Vitamin D25 nmol/L ref 50-150
Folates<5 nmol/L ref >7.9
Lipoprotein(a)106 nmol/L ref <75, genetic CVD marker
CRP6 mg/L slightly elevated
Body fat~22-25% at 179cm

Re-panel at week 12. Results published when available.

What we did

  • Supplements

    Vitamin D and folate protocol. Cardiovascular optimization plan built around the Lp(a) result.

  • Sleep

    Wind-down protocol. Caffeine timing restructured (cut-off at 1pm, energy drinks removed).

  • Training

    Body recomposition target: 75 kg with increased lean mass.

  • Diagnostics

    Full re-panel at week 12.

Case 06

Elevated TSH, H. pylori positive, thought feeling terrible was just how he was built.

Role Operator Program length Ongoing Status Ongoing

Bad mornings, daytime naps just to function, long unmotivated stretches with no obvious cause, and low mood on random days. He was building a business on a processed-food diet, training when he could, and sleeping inconsistently. His own explanation was simply that this was how he felt. His panel had a very different explanation.

The first panel came back with elevated TSH, elevated free T3, free testosterone sitting at the very bottom of the range, a positive H. pylori result, and insufficient vitamin D. Three reversible drivers and one bacterial infection, none of which a standard annual checkup would have caught. We do not write diagnoses here, we address markers, and his re-panel is scheduled for week twelve.

Week 0 · Feb 2026 Multiple markers flagged
TSH7.349 uIU/mL ref 0.35-5.5
Free T34.82 pg/mL ref 2.3-4.2
Vitamin D21.7 ng/mL insufficient
Free testosterone9.96 pg/mL bottom of range
Estradiol34.4 pg/mL elevated
H. pyloriPositive 314 cpm, ref >=50 positive

Re-panel at week 12. Results published when available.

What we did

  • Medical

    H. pylori addressed via medical referral. Full eradication protocol initiated.

  • Nutrition

    Diet rebuilt off processed food. Whole food protocol supporting thyroid and hormonal recovery.

  • Sleep

    Sleep consistency protocol. Schedule fixed, monitoring via Whoop.

  • Training

    Consistency protocol. Structured program built around his schedule.

  • Supplements

    Vitamin D protocol.

Start with a conversation.

It is thirty minutes, nothing more. We look honestly at where your health is right now, where it needs to be for the next phase of what you are building, and whether the twelve-week program is the right move for you. Sometimes it is not, and if that is the case I will tell you so on the call.

Work with me

Reviewed and accepted on a case-by-case basis. We do not work with everyone who books.

All cases shown are real, anonymized with written client consent. Calibrate Health provides performance coaching and health optimization consulting. We do not diagnose, treat, or prescribe. All diagnostic testing is conducted through accredited third-party clinical providers. Results vary based on individual baseline, adherence, and biology.