A few real cases, with the panels and timestamps intact and every identifying detail removed.
We have worked with dozens of clients at this point. It would not make much sense to document all of them here. These are a few recent cases, shown purely for demonstration purposes. All clients consented to anonymous publication of their data. No names, no identifying details. The panels are real. The timestamps are real. The protocols that produced the changes are summarized but not published in full.
A fifty-year-old founder running a real business. From the outside everything looked dialled in, and he believed it was. The first panel said otherwise. His cholesterol was out of range across every marker, his liver enzymes were elevated in a pattern consistent with fatty liver, he was carrying significant excess weight, his energy was gone, and his focus came and went without any pattern he could name.
Twenty weeks later he was seventeen kilograms lighter, with every flagged marker back in range, his liver indicators resolved, his energy back, and his focus restored. None of it was exotic. It was the right system built across all six blocks and then run, without skipping, for twenty weeks straight.
| Body weight | 99 kg |
| Total cholesterol | 222 mg/dL |
| LDL cholesterol | 179 mg/dL |
| HDL cholesterol | 22 mg/dL |
| AST (liver) | 95 U/L |
| ALT (liver) | 217 U/L |
| Body weight | 82 kg |
| Total cholesterol | 172 mg/dL |
| LDL cholesterol | 107 mg/dL |
| HDL cholesterol | 49 mg/dL |
| AST (liver) | 27 U/L |
| ALT (liver) | 25 U/L |
Restructured macros around liver recovery. Removed inflammatory drivers. Built a sustainable eating pattern around his travel schedule.
Returning from a 3-month break. Started with full-body resistance protocol 5x/week, added zone-2 cardio for metabolic recovery.
Sleep window restructured. Weekend consistency built up over weeks 1 through 6.
Re-panel at week 10 and week 20 to confirm direction and re-calibrate.
Weekly 1:1 calls, daily communication, real-time protocol adjustments.
Fifty-eight years old, fasting intermittently, playing competitive padel three times a week, eating clean, and completely convinced he was operating at his peak. He only came to the program because a friend insisted, not because he thought anything was wrong.
His first panel showed inflammation at thirty times the upper reference, microcytic red cells, and a recent bout of malaria that had never fully resolved. The protocols he was running, intermittent fasting stacked on top of high-intensity padel, are perfectly sensible for a healthy person. He was not a healthy person at that point. So we took the high-intensity load off, rebuilt his nutrition around recovery rather than restriction, and put a strength program around the depleted state he was actually in.
| C-Reactive Protein | 149 mg/L ref < 5 |
| RBC | 5.93 x10¹²/L ref 4.5–5.5 |
| MCV | 71.5 fL ref 83–101 |
| MCH | 22.1 pg ref 27–32 |
Re-panel scheduled for week 12. Results published when available.
Removed high-intensity padel. Built a recovery-first strength protocol.
Stopped intermittent fasting. Rebuilt nutrient timing around recovery.
Full re-panel scheduled at week 12.
Weekly 1:1, recovery-focused weekly check-ins.
Yes, this is me. I include my own panel because running a health optimization company without being a client of your own program would be a bit awkward. For context: I have been training and optimizing seriously for about seven years, and for the last four to five of those I have been genuinely operating at a top 1% baseline. Good sleep, good nutrition, consistent training, full diagnostics run regularly. This is not a case of someone coming in broken. It is a case of what a 150-marker panel finds even when everything feels right.
The two markers worth explaining are SHBG and free testosterone. Total testosterone is strong. SHBG is elevated, which suppresses free testosterone (the form the body actually uses) to the lower end of the range. This is largely a consequence of a known exposure: eight months of isotretinoin in my teens for severe acne. Isotretinoin puts significant load on the liver, and elevated SHBG is a well-documented downstream effect in some cases. It is not a performance crisis. It is a specific target. The protocol is built around lowering SHBG through zone-2 training, gut support, and sleep consistency, and tracking whether free T follows up over the next panel.
The broader point is this: if a panel run on someone already optimizing seriously still finds actionable targets, imagine what it finds on someone who has never tested at all.
| Total testosterone | 658 ng/dL looks fine, hides the problem |
| Free testosterone | 19.8 pg/mL ref 19.0–51.0 |
| SHBG | 53.9 nmol/L high, suppressing free T |
| Vitamin D | 24 ng/mL ref 30–100 |
| F. prausnitzii (gut) | 0.98% ref 3.44–11.31 |
Re-panel scheduled for week 12. Results published when available.
Added zone-2 cardio block to existing strength protocol to lower SHBG and improve HRV.
Gut-targeted protocol to rebuild F. prausnitzii (butyrate-producing keystone species).
Vitamin D protocol, gut-supportive stack.
Consistency rebuild (Whoop showed 71% consistency, poor).
Full re-panel at week 12.
He started at 96 kilograms with elevated insulin and metabolic markers consistent with early insulin resistance. He had never had a baseline panel done, so he genuinely did not know what a healthy operating baseline looked like, because no one had ever measured his properly. The work was not a diet. It was rebuilding an entire operating system from the ground up, with sleep, nutrition, training, habits, and diagnostics all running in parallel from day one.
At six months he was 73 kilograms, down twenty-three, with his insulin markers reversed and his energy finally stable. He is still progressing.
| Body weight | 96 kg |
| Fasting insulin | Elevated insulin resistance pattern |
| Body composition | Excess fat mass DEXA confirmed |
| Body weight | 73 kg -23 kg |
| Fasting insulin | In range |
| Body composition | Significantly improved |
Complete diet overhaul. Built a whole-food protocol addressing the insulin pattern and supporting body recomposition.
Progressive resistance program plus structured cardio. Built from zero, scaled over 6 months.
Full sleep optimization protocol. Schedule, environment, consistency tracking.
Weekly 1:1 calls, daily check-ins, habit system built around the client's schedule.
Baseline panel, re-panel at month 3, ongoing monitoring.
He was building a business, training five days a week, and looked completely fine from the outside. The standard ten-marker checkup agreed with that and called him normal. The 150-marker panel did not. It found three reversible deficiencies and one genetic cardiovascular risk marker, Lipoprotein(a), that most general practitioners never think to test for. That marker does not respond to lifestyle the way the others do, but the risk it carries can be substantially offset by optimizing everything around it, and that is exactly what his protocol was built to do.
The sleep problem he mentioned turned out to be work stress and an inability to switch off, on top of two or three coffees and energy drinks a day. His re-panel is scheduled for week twelve.
| Vitamin D | 25 nmol/L ref 50-150 |
| Folates | <5 nmol/L ref >7.9 |
| Lipoprotein(a) | 106 nmol/L ref <75, genetic CVD marker |
| CRP | 6 mg/L slightly elevated |
| Body fat | ~22-25% at 179cm |
Re-panel at week 12. Results published when available.
Vitamin D and folate protocol. Cardiovascular optimization plan built around the Lp(a) result.
Wind-down protocol. Caffeine timing restructured (cut-off at 1pm, energy drinks removed).
Body recomposition target: 75 kg with increased lean mass.
Full re-panel at week 12.
Bad mornings, daytime naps just to function, long unmotivated stretches with no obvious cause, and low mood on random days. He was building a business on a processed-food diet, training when he could, and sleeping inconsistently. His own explanation was simply that this was how he felt. His panel had a very different explanation.
The first panel came back with elevated TSH, elevated free T3, free testosterone sitting at the very bottom of the range, a positive H. pylori result, and insufficient vitamin D. Three reversible drivers and one bacterial infection, none of which a standard annual checkup would have caught. We do not write diagnoses here, we address markers, and his re-panel is scheduled for week twelve.
| TSH | 7.349 uIU/mL ref 0.35-5.5 |
| Free T3 | 4.82 pg/mL ref 2.3-4.2 |
| Vitamin D | 21.7 ng/mL insufficient |
| Free testosterone | 9.96 pg/mL bottom of range |
| Estradiol | 34.4 pg/mL elevated |
| H. pylori | Positive 314 cpm, ref >=50 positive |
Re-panel at week 12. Results published when available.
H. pylori addressed via medical referral. Full eradication protocol initiated.
Diet rebuilt off processed food. Whole food protocol supporting thyroid and hormonal recovery.
Sleep consistency protocol. Schedule fixed, monitoring via Whoop.
Consistency protocol. Structured program built around his schedule.
Vitamin D protocol.
It is thirty minutes, nothing more. We look honestly at where your health is right now, where it needs to be for the next phase of what you are building, and whether the twelve-week program is the right move for you. Sometimes it is not, and if that is the case I will tell you so on the call.
Work with meReviewed and accepted on a case-by-case basis. We do not work with everyone who books.
All cases shown are real, anonymized with written client consent. Calibrate Health provides performance coaching and health optimization consulting. We do not diagnose, treat, or prescribe. All diagnostic testing is conducted through accredited third-party clinical providers. Results vary based on individual baseline, adherence, and biology.